Description

1-Fluoro-4-Nitrobutane is a versatile fluorinated nitroalkane building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a reactive nitro group and a fluorine atom, makes it a valuable precursor for the development of novel pharmaceuticals, agrochemicals, and specialty materials. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atom can improve biological activity and environmental persistence profiles.
• Fluorinated Building Block: Employed in organic synthesis for introducing fluorine-containing functional groups via reactions of the nitro group, such as Nef reactions or reductions to amines.
• Material Science Precursor: Acts as a monomer or modifier in the research of specialty polymers and advanced materials with tailored surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes and tags for studying biological systems and mechanisms.

Basic Information

Product Name	1-Fluoro-4-Nitrobutane
CAS No.	372-82-7
Molecular Formula	C₄H₈FNO₂
Molecular Weight	121.11 g/mol
Synonyms	4-Nitro-1-fluorobutane; Butane, 1-fluoro-4-nitro-; 1-Fluorobutane-4-nitrate; 4-Nitrobutyl fluoride; γ-Nitrobutyl fluoride; NSC 60545; F(CH₂)₄NO₂
EINECS	206-759-5

Quality Control

Our 1-Fluoro-4-Nitrobutane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.420 - 1.425
Density (g/mL at 20°C)	1.18 - 1.22

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.