Description

6-Fluoro-1-Hexanesulfonyl Fluoride is a versatile fluorinated sulfonyl fluoride building block, essential for introducing the sulfonyl fluoride functional group into target molecules. Its value lies in its reactivity, enabling the synthesis of complex sulfonamides and sulfonate esters under mild conditions, which is critical for advanced material and pharmaceutical development. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for applications in medicinal chemistry, chemical biology, and polymer modification.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of novel sulfonamide-based drug candidates, particularly in kinase inhibitor and protease inhibitor research.
• Chemical Biology Probe Synthesis: Used in activity-based protein profiling (ABPP) to create covalent probes for studying enzyme function and target engagement.
• Agrochemical Development: Serves as a building block for creating new sulfonylurea or sulfonamide herbicides and pesticides with improved properties.
• Polymer & Material Science: Employed to functionalize polymers and surfaces, introducing sulfonyl fluoride groups for subsequent click-chemistry modifications to alter material properties.
• Ligand & Catalyst Design: Facilitates the creation of specialized ligands and organocatalysts containing the sulfonyl fluoride motif for asymmetric synthesis.
• Radiochemistry: Potential precursor for the synthesis of fluorine-18 labeled tracers for Positron Emission Tomography (PET) imaging, given the presence of a fluorine atom.

Basic Information

Product Name	6-Fluoro-1-Hexanesulfonyl Fluoride
CAS No.	372-70-3
Molecular Formula	C6H12F2O2S
Molecular Weight	186.22 g/mol
Synonyms	1-Hexanesulfonyl fluoride, 6-fluoro-; 6-Fluorohexane-1-sulfonyl fluoride; 6-Fluorohexylsulfonyl fluoride; ω-Fluorohexanesulfonyl fluoride; 6-Fluoro-1-hexylsulfonyl fluoride; FSO2(CH2)5CH2F; Hexanesulfonyl fluoride, 6-fluoro-
EINECS	Contact for details

Quality Control

Our 6-Fluoro-1-Hexanesulfonyl Fluoride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and identity confirmation. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Assay (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.