Description

3',4'-Difluoroacetophenone is a versatile fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the aromatic ring, which significantly influences the electronic properties and metabolic stability of final compounds. This intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of novel drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the difluoro motif enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated liquid crystals and organic light-emitting diode (OLED) components.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique thermal, chemical, or surface properties.
• Cross-Coupling Reactions: Acts as an electrophile in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to build complex molecular architectures.
• Chemical Research & Development: A fundamental reagent for exploring new fluorination chemistry and reaction pathways in academic and industrial labs.

Basic Information

Product Name	3',4'-Difluoroacetophenone
CAS No.	369-33-5
Molecular Formula	C8H6F2O
Molecular Weight	156.13 g/mol
Synonyms	1-(3,4-Difluorophenyl)ethanone; 3,4-Difluoroacetophenone; 3,4-DFAP; 3,4-Difluorophenyl methyl ketone; m,p-Difluoroacetophenone; Ethanone, 1-(3,4-difluorophenyl)-; 3,4-Difluoroacetylbenzene
EINECS	206-719-8

Quality Control

Our 3',4'-Difluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥98.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.