Description

Butyl 2,2-Difluoroacetate is a specialized fluorinated ester building block, valued for its unique reactivity and role in introducing the difluoroacetate moiety into target molecules. This compound is essential for synthetic chemists developing novel active ingredients in the pharmaceutical and agrochemical sectors, where the difluoromethyl group can significantly alter metabolic stability and biological activity. It serves as a key intermediate for researchers and manufacturers in fine chemical synthesis, advanced material science, and the development of fluorinated liquid crystals or polymers.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) containing difluoromethyl or difluoroacetate groups, which can enhance drug potency and pharmacokinetic properties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where fluorination improves efficacy and environmental stability.
• Fluorinated Liquid Crystal Precursor: Serves as a starting material for synthesizing fluorinated compounds used in liquid crystal displays (LCDs) to optimize their electro-optical properties.
• Polymer & Material Science: Employed as a monomer or modifier to create fluorinated polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Organic Synthesis Reagent: Acts as an electrophilic difluoroacetylating agent in various organic transformations, including esterifications and nucleophilic substitutions.
• Flavor & Fragrance Intermediate: Utilized in the research and development of novel fluorinated aroma chemicals, although final use is subject to strict regulatory approval.

Basic Information

Product Name	Butyl 2,2-Difluoroacetate
CAS No.	368-35-4
Molecular Formula	C6H10F2O2
Molecular Weight	152.14 g/mol
Synonyms	2,2-Difluoroacetic Acid Butyl Ester; n-Butyl 2,2-Difluoroacetate; Butyl Difluoroacetate; Difluoroacetic Acid Butyl Ester; Butoxycarbonylfluoromethane; EINECS 206-712-4
EINECS	206-712-4

Quality Control

Our Butyl 2,2-Difluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from strong bases and incompatible materials. Due to its highly volatile nature, keep containers tightly sealed when not in use and handle in a fume hood. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	1.08 - 1.12 g/mL
Refractive Index (n20D)	1.380 - 1.390

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.