Description

1-Benzyloxy-2-Fluoro-Benzene is a high-purity fluorinated aromatic ether building block of significant importance in advanced organic synthesis. Its core value lies in its versatile benzyl-protected phenolic structure, which serves as a critical intermediate for constructing complex molecules in regulated industries. This compound is essential for research and development chemists and process engineers working in pharmaceuticals and agrochemicals, where the introduction of fluorine atoms is a key strategy for modulating the biological activity and metabolic stability of target compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated phenyl ether moiety.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the fluorine atom enhances efficacy and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores in electronic and display materials.
• Organic Ligand & Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A valuable reagent for method development and exploring new fluorination pathways in organic chemistry.
• Fine Chemical Production: Used in the multi-step synthesis of complex dyes, flavors, and fragrances.

Basic Information

Product Name	1-Benzyloxy-2-Fluoro-Benzene
CAS No.	368-21-8
Molecular Formula	C₁₃H₁₁FO
Molecular Weight	202.22 g/mol
Synonyms	2-Fluorophenyl benzyl ether; Benzyl 2-fluorophenyl ether; o-Fluorophenyl benzyl ether; 1-Fluoro-2-(benzyloxy)benzene; 2-Fluorodiphenyl ether, benzyl-; (2-Fluorophenoxy)methyl]benzene; NSC 406916
EINECS	Contact for details

Quality Control

Our 1-Benzyloxy-2-Fluoro-Benzene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.