Description

Ethyl 2-Fluoro-5-Nitrobenzoate is a high-purity organic building block characterized by its fluorinated aromatic nitro ester structure. This compound is valued for its role as a versatile intermediate in advanced organic synthesis, particularly in the construction of complex molecules for pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atom and nitro group are critical for biological activity.
• Material Science: Serves as a building block for advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing nitro and ester functionalities.
• Dye and Pigment Synthesis: Employed in the production of specialized dyes and pigments where fluorinated intermediates can alter light absorption and color fastness properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing biaryl systems, a common motif in medicinal chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes and tags for studying biological processes and enzyme mechanisms.

Basic Information

Product Name	Ethyl 2-Fluoro-5-Nitrobenzoate
CAS No.	367-79-3
Molecular Formula	C9H8FNO4
Molecular Weight	213.16 g/mol
Synonyms	2-Fluoro-5-nitrobenzoic Acid Ethyl Ester; Benzoic acid, 2-fluoro-5-nitro-, ethyl ester; Ethyl 2-fluoro-5-nitrobenzoate; 5-Nitro-2-fluorobenzoic Acid Ethyl Ester; Ethyl 5-nitro-2-fluorobenzoate; NSC 406079; 367-79-3; 2-Fluoro-5-nitro-benzoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Fluoro-5-Nitrobenzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in cGMP environments and research requiring the highest standards of material integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and should be stored away from direct light. It is also easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening a new container to prevent degradation. Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.