Description

(2,2,2-Trifluoro-Acetylamino)-Acetic Acid Ethyl Ester is a high-value trifluoroacetyl-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a protected glycine moiety with enhanced lipophilicity and metabolic stability, which is essential for developing novel bioactive compounds. This intermediate is particularly sought after by pharmaceutical and agrochemical R&D teams for the synthesis of peptides, peptidomimetics, and other complex molecules where the trifluoroacetyl group acts as a versatile protecting group.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in peptide and protease inhibitor research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the trifluoromethyl group confers desirable biological activity and environmental stability.
• Peptide Chemistry: Serves as a protected glycine derivative for solid-phase and solution-phase peptide synthesis, facilitating the creation of complex peptide libraries.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and labeled compounds for biochemical and diagnostic applications.
• Material Science Research: Acts as a monomer or precursor for specialty polymers and advanced materials with unique surface properties.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic synthesis and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	(2,2,2-Trifluoro-Acetylamino)-Acetic Acid Ethyl Ester
CAS No.	367-62-4
Molecular Formula	C6H8F3NO3
Molecular Weight	199.13 g/mol
Synonyms	N-(Trifluoroacetyl)glycine ethyl ester; Ethyl N-(trifluoroacetyl)glycinate; Glycine, N-(trifluoroacetyl)-, ethyl ester; Ethyl 2-[(trifluoroacetyl)amino]acetate; 2-(Trifluoroacetamido)acetic acid ethyl ester; N-Trifluoroacetylglycine ethyl ester; TFA-Gly-OEt
EINECS	206-698-1

Quality Control

Our (2,2,2-Trifluoro-Acetylamino)-Acetic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is sensitive to moisture and strong bases; ensure the container is kept tightly sealed in a dry environment. Segregate from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.