Description

1,1,3,3-Tetrafluoroacetone is a highly fluorinated ketone building block, valued for its unique reactivity and ability to introduce trifluoromethyl and difluoromethylene groups into complex molecules. Its primary commercial significance lies in serving as a key intermediate for synthesizing advanced fluorinated pharmaceuticals, agrochemicals, and specialty materials. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced material sectors seeking to enhance the metabolic stability, lipophilicity, and bioavailability of their target molecules.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs) containing CF3 groups, which are prevalent in modern drug discovery for improved drug properties.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides where fluorine incorporation increases efficacy and environmental stability.
• Fluorinated Material Precursor: Serves as a building block for specialty polymers, liquid crystals, and coatings that require specific thermal, chemical, or surface properties.
• Organic Synthesis Reagent: Employed in nucleophilic addition reactions, Grignard reactions, and as a precursor for various fluorinated heterocycles and complex organic structures in research laboratories.
• Electrolyte Additive Research: Investigated for use in lithium-ion battery electrolytes to improve stability and performance at high voltages.

Basic Information

Product Name	1,1,3,3-Tetrafluoroacetone
CAS No.	360-52-1
Molecular Formula	C3H2F4O
Molecular Weight	130.04 g/mol
Synonyms	1,1,3,3-Tetrafluoro-2-propanone; Perfluoroacetone (common name); 2-Propanone, 1,1,3,3-tetrafluoro-; TFAP; 1,1,3,3-Tetrafluoroacetone; 3,3,3-Trifluoro-2-(trifluoromethyl)propanoic acid (related acid form); Bis(trifluoromethyl) ketone; Hexafluoroacetone (isomer, note: different compound); F3CC(O)CF3H
EINECS	206-634-1

Quality Control

Our 1,1,3,3-Tetrafluoroacetone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and reducing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed and at a consistent, cool temperature (recommended 2-8°C or as specified on the label) to minimize loss and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.