Description

α,α-Difluorophenylacetic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethyl group adjacent to a carboxylic acid, making it a critical intermediate for constructing complex molecules. This compound is essential for research and production facilities in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key synthon for the production of non-steroidal anti-inflammatory drugs (NSAIDs) and other active pharmaceutical ingredients (APIs) containing difluorophenyl motifs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and pesticides, where the fluorine atoms can improve metabolic stability and bioavailability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic displays.
• Organic Light-Emitting Diodes (OLEDs): A building block for creating fluorinated charge-transport or emissive materials.
• Peptide Mimetics & Medicinal Chemistry: Employed to introduce rigid, lipophilic difluorophenyl groups into peptide backbones or drug candidates to modulate their pharmacokinetic profiles.
• Cross-Coupling Reactions: The carboxylic acid group can be readily derivatized or the compound can be used to prepare organometallic reagents for Suzuki, Negishi, or other cross-coupling methodologies.

Basic Information

Product Name	α,α-Difluorophenylacetic Acid
CAS No.	360-03-2
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	2,2-Difluoro-2-phenylacetic Acid; (Difluorophenyl)acetic Acid; α,α-Difluorobenzeneacetic Acid; 2,2-Difluorophenylacetic Acid; DFPAA; Phenyl(difluoro)acetic Acid; NSC 406106; Difluorophenylacetic Acid
EINECS	206-630-6

Quality Control

We supply α,α-Difluorophenylacetic Acid in high-purity grades suitable for demanding synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to a strict quality management system to guarantee batch-to-batch consistency and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. The compound is light-sensitive (store away from light) and should be handled in a manner that minimizes exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	88 - 92 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.