Description

N,n-Bis(Trifluoromethyl)Hydroxylamine is a specialized fluorinated hydroxylamine derivative with the CAS number 359-63-7. This compound is a valuable building block in advanced organic synthesis, prized for its ability to introduce the highly stable and lipophilic bis(trifluoromethyl)amino group into target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Precursor: Serves as a precursor for specialized ligands in coordination chemistry and catalysis, enabling unique reaction pathways.
• Advanced Material Development: Incorporated into polymers and specialty chemicals to impart desirable properties such as chemical resistance, low surface energy, or thermal stability.
• Fluorination Reagent: Acts as a source of the N(CF3)2 moiety in nucleophilic or radical fluorination reactions to construct complex fluoroorganic molecules.
• Energetic Materials Research: Investigated for potential use in the formulation of high-energy-density materials (HEDMs) due to its unique nitrogen-oxygen and fluorine content.

Basic Information

Product Name	N,n-Bis(Trifluoromethyl)Hydroxylamine
CAS No.	359-63-7
Molecular Formula	C2HF6NO
Molecular Weight	181.03 g/mol
Synonyms	Hydroxylamine, N,N-bis(trifluoromethyl)-; Bis(trifluoromethyl)hydroxylamine; N,N-Bis(trifluoromethyl)hydroxylamine; DTXSID00155095; NSC 163046; 1,1,1,3,3,3-Hexafluoro-N-hydroxy-2-azapropane-2-imine
EINECS	Contact for details

Quality Control

Our N,n-Bis(Trifluoromethyl)Hydroxylamine is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot undergoes comprehensive analytical testing, including assay by NMR or HPLC, identity confirmation (IR), and impurity profiling. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and fluoride/strong alkali nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.