Description

1,1,1-Trifluoro-3,3-Dimethylbutan-2-Ol CAS NO 359-60-4 is a fluorinated tertiary alcohol, a versatile building block prized for its unique combination of steric bulk and fluorine-induced electronic effects. This compound is critical for researchers and manufacturers developing advanced materials and pharmaceuticals where precise molecular tuning is required. It is primarily utilized in the synthesis of specialty chemicals, agrochemicals, and as a key intermediate for ligands and catalysts in asymmetric synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for introducing the trifluoromethyl group and tert-butyl-like steric bulk into drug candidates, potentially enhancing metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atoms can improve lipophilicity and biological activity.
• Specialty Polymer & Material Science: Acts as a monomer or modifier for creating fluorinated polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Catalyst & Ligand Design: Employed in the preparation of sophisticated chiral ligands and organocatalysts for enantioselective synthesis in fine chemical production.
• Organic Synthesis Building Block: Provides a robust scaffold for constructing complex molecular architectures in research and process chemistry.
• Electronic Chemicals: Investigated for use in the formulation of specialty solvents and etching agents in the semiconductor industry.

Basic Information

Product Name	1,1,1-Trifluoro-3,3-Dimethylbutan-2-Ol
CAS No.	359-60-4
Molecular Formula	C6H11F3O
Molecular Weight	156.15 g/mol
Synonyms	1,1,1-Trifluoro-3,3-dimethyl-2-butanol; 2-Butanol, 1,1,1-trifluoro-3,3-dimethyl-; 3,3-Dimethyl-1,1,1-trifluorobutan-2-ol; TFDB; Hexafluoro-tert-butanol (common misnomer, verify structure); (CF3)2C(OH)CH(CH3)2 (skeletal representation); α,α,α-Trifluoro-3,3-dimethyl-2-butanol
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-3,3-Dimethylbutan-2-Ol is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for manufacturing where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to minimize moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.380 - 1.390
Density (20°C)	1.10 - 1.20 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.