Description

2,3,3,3-Tetrafluoropropanoic Acid is a versatile fluorinated carboxylic acid building block of significant industrial importance. Its unique structure, featuring a high fluorine content, imparts valuable properties such as enhanced acidity, lipophilicity, and metabolic stability to derived compounds. This makes it a critical intermediate for researchers and manufacturers in advanced chemical synthesis. Key industries that utilize this compound include pharmaceuticals, agrochemicals, and materials science for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Production of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Key precursor for fluorine-containing monomers and polymers used in display technologies and specialty coatings.
• Organic Synthesis Building Block: Used in reactions to introduce the tetrafluoropropanoic acid moiety or as a precursor for other fluorinated compounds like acid halides or esters.
• Catalyst & Ligand Preparation: Employed in the development of metal-organic frameworks (MOFs) and specialized catalysts for fluorination reactions.
• Surface Active Agent Intermediate: Manufacture of fluorinated surfactants and surface treatment agents with low surface energy.

Basic Information

Product Name	2,3,3,3-Tetrafluoropropanoic Acid
CAS No.	359-49-9
Molecular Formula	C₃H₂F₄O₂
Molecular Weight	146.04 g/mol
Synonyms	2,3,3,3-Tetrafluoropropionic Acid; Perfluoropropionic Acid (common misnomer); TFPA; Tetrafluoropropanoic Acid; 3,3,3-Trifluoro-2-(trifluoromethyl)propanoic Acid (alternative IUPAC); 359-49-9; NSC 92366; EINECS 206-631-7
EINECS	206-631-7

Quality Control

Every batch of 2,3,3,3-Tetrafluoropropanoic Acid is produced and tested under a strict quality management system. We provide comprehensive analytical documentation to ensure product integrity and traceability for your regulatory needs. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot upon request. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, oxidizers, and reducing agents. Due to its nature as a strong acid/organic solvent, containers must be kept tightly sealed and constructed of compatible materials (e.g., PTFE, fluoropolymer-lined). Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Refractive Index (n20D)	1.300 - 1.330
Density (g/mL at 20°C)	1.45 - 1.55

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.