Description

2,2-Difluoroacetamide is a versatile fluorinated organic compound with the CAS number 359-38-6, serving as a critical building block in advanced chemical synthesis. Its unique difluoroacetamide structure makes it a valuable precursor for introducing fluorine atoms into target molecules, enhancing their metabolic stability and lipophilicity. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where fluorine incorporation improves efficacy and environmental profile.
• Fluorinated Material Precursor: Serves as a starting material for synthesizing fluorinated polymers, surfactants, and liquid crystals.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and condensation reactions to introduce the difluoroacetamide moiety.
• Biochemical Research: Utilized in medicinal chemistry research for structure-activity relationship (SAR) studies and probe molecule development.
• Fine Chemical Production: Intermediate in the manufacture of specialty fluorinated fine chemicals and dyes.

Basic Information

Product Name	2,2-Difluoroacetamide
CAS No.	359-38-6
Molecular Formula	C2H3F2NO
Molecular Weight	95.05 g/mol
Synonyms	Difluoroacetamide; 2,2-Difluoroethanamide; α,α-Difluoroacetamide; Acetamide, 2,2-difluoro-; NSC 3771; DFAA; DFA
EINECS	Contact for details

Quality Control

Our 2,2-Difluoroacetamide is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.