Description

Difluoroacetonitrile is a versatile and highly reactive fluorinated building block essential for advanced organic synthesis. Its primary value lies in introducing the difluoromethylnitrile (-CF2CN) moiety, a key precursor to difluoromethyl groups and other fluorine-containing heterocycles. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to incorporate fluorine atoms to modulate the biological activity, metabolic stability, and lipophilicity of target molecules.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel active pharmaceutical ingredients (APIs), especially in protease inhibitors and kinase-targeted therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where fluorine atoms enhance efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or building block for specialty polymers and advanced materials with unique surface properties.
• Fluorinated Heterocycle Construction: Key reactant in the synthesis of fluorinated pyrimidines, pyridines, and other nitrogen-containing heterocycles.
• Ligand and Catalyst Development: Employed in the preparation of novel fluorinated ligands for catalysis and molecular recognition applications.
• Research & Development: An important reagent in medicinal chemistry and discovery chemistry programs for structure-activity relationship (SAR) studies.

Basic Information

Item	Detail
Product Name	Difluoroacetonitrile
CAS No.	359-12-6
Molecular Formula	C2HF2N
Molecular Weight	77.03 g/mol
Synonyms	2,2-Difluoroacetonitrile; Difluoromethyl cyanide; Acetonitrile, 2,2-difluoro-; DIFLUOROACETONITRILE; 359-12-6; 2,2-Difluoroethanenitrile; NSC 3776
EINECS	Contact for details

Quality Control

Our Difluoroacetonitrile is produced and handled under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including Gas Chromatography (GC) and Nuclear Magnetic Resonance (NMR) spectroscopy, to ensure high purity and consistent performance. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles against our rigorous internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated area, away from heat sources and open flames. Recommended storage temperature is 2-8°C. Keep the container tightly sealed under an inert atmosphere to maintain purity and prevent moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.