Description

1-Chloromethyl-2,2,3,3-tetrafluorocyclobutane is a specialized fluorinated cyclobutane derivative that serves as a valuable building block in advanced chemical synthesis. Its unique structure, featuring a reactive chloromethyl group on a perfluorinated ring, makes it a critical intermediate for introducing fluorinated motifs into target molecules. This compound is primarily sought by R&D chemists and process development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients with enhanced properties such as metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated drug candidates, potentially improving bioavailability and patent life.
• Agrochemical Synthesis: Used in creating advanced fluorinated pesticides and herbicides with increased efficacy and environmental persistence.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty fluoropolymers with unique thermal and chemical resistance.
• Liquid Crystal & Electronic Chemicals: A precursor for fluorinated components in liquid crystal displays (LCDs) and dielectric fluids.
• Organic Synthesis Building Block: Employed in academic and industrial labs for constructing complex, fluorinated organic frameworks via nucleophilic substitution reactions.

Basic Information

Product Name	1-Chloromethyl-2,2,3,3-Tetrafluorocyclobutane
CAS No.	356-80-9
Molecular Formula	C5H5ClF4
Molecular Weight	176.54 g/mol
Synonyms	1-(Chloromethyl)-2,2,3,3-tetrafluorocyclobutane; (Chloromethyl)tetrafluorocyclobutane; Tetrafluoro(1-chloromethyl)cyclobutane; 2,2,3,3-Tetrafluoro-1-chloromethylcyclobutane; Cyclobutane, 1-(chloromethyl)-2,2,3,3-tetrafluoro-; NSC 163082
EINECS	Contact for details

Quality Control

Our 1-Chloromethyl-2,2,3,3-tetrafluorocyclobutane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and active metals. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to minimize moisture uptake and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.