Description

Trifluoroacetonitrile is a highly versatile and reactive fluorinated building block, essential for introducing the trifluoromethyl group into complex molecular architectures. Its primary value lies in its role as a key precursor in the synthesis of pharmaceuticals, agrochemicals, and advanced materials, where the CF3 moiety imparts desirable properties like enhanced metabolic stability and lipophilicity. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel compounds and developing new synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs) containing the trifluoromethyl group, particularly in antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves biological activity and environmental persistence.
• Material Science: Serves as a monomer or precursor for fluorinated polymers, liquid crystals, and electronic materials that require specific dielectric properties and chemical resistance.
• Organic Synthesis Reagent: Employed in cycloaddition reactions, as an electrophile in nucleophilic additions, and for the preparation of heterocycles like trifluoromethyl-substituted pyrazoles and triazoles.
• Ligand and Catalyst Development: Utilized to synthesize novel fluorinated ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine-19 NMR Spectroscopy: Can be used as a reference standard or a chemical shift reagent in analytical chemistry.

Basic Information

Product Name	Trifluoroacetonitrile
CAS No.	353-85-5
Molecular Formula	C2F3N
Molecular Weight	95.03 g/mol
Synonyms	Trifluoroethanenitrile; Perfluoroacetonitrile; 2,2,2-Trifluoroacetonitrile; Trifluoromethyl cyanide; TFAN; CF3CN; NSC 7605
EINECS	206-539-1

Quality Control

Our Trifluoroacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including Gas Chromatography (GC) and NMR spectroscopy, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, containers must be kept tightly sealed and under appropriate pressure. Recommended storage temperature is 2-8°C to minimize pressure buildup and maintain stability. Keep away from strong bases, reducing agents, and moisture.

Specification

Item	Specification
Appearance	Colorless liquid / gas
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Acidity (as HF)	≤ 0.05%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.