Description

4-Fluorobutyl Isocyanate is a versatile fluorinated building block essential for introducing the isocyanate functional group into complex molecular architectures. Its value lies in enabling the synthesis of novel compounds with enhanced properties for advanced material and life science applications. This high-purity intermediate is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and pesticides with improved efficacy and environmental profiles.
• Polymer Modification: Serves as a functional monomer or cross-linking agent for creating specialty polyurethanes and fluorinated polymers with unique surface properties.
• Liquid Crystal & OLED Materials: A precursor for synthesizing fluorinated components used in advanced display and lighting technologies.
• Bioconjugation & Probe Development: Facilitates the labeling of biomolecules (proteins, peptides) for diagnostic assays and biochemical research due to its reactive isocyanate group.
• Covalent Organic Framework (COF) Synthesis: Employed as a linker molecule in the construction of porous, crystalline materials for gas storage and catalysis.

Basic Information

Product Name	4-Fluorobutyl Isocyanate
CAS No.	353-16-2
Molecular Formula	C5H8FNO
Molecular Weight	117.12 g/mol
Synonyms	1-Fluoro-4-isocyanatobutane; 4-Fluorobutane-1-isocyanate; 4-Fluorobutyl isocyanate; Butane, 1-fluoro-4-isocyanato-; 4-Fluorobutylisocyanate; 1-Isocyanato-4-fluorobutane; 4-Fluorobutyl isocyanic acid ester; 4-Fluorobutyl ester of isocyanic acid
EINECS	Contact for details

Quality Control

Our 4-Fluorobutyl Isocyanate is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications. We support cGMP and ISO 9001 standards for our manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to maximize stability. Due to its moisture-sensitive (hygroscopic) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as water, alcohols, amines, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Density (at 20°C)	~1.08 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.