Description

4-(Trifluoromethoxy)Fluorobenzene is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, makes it a critical intermediate for introducing lipophilicity and metabolic stability into target molecules. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in CNS and oncology drug candidates.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides requiring fluorinated motifs for enhanced efficacy.
• Liquid Crystal Materials: Serves as a building block for fluorine-containing liquid crystals used in display technologies.
• Organic Electronics: Employed in the synthesis of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Fluorine Chemistry Research: Essential reagent in academic and industrial R&D for exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	4-(Trifluoromethoxy)Fluorobenzene
CAS No.	352-67-0
Molecular Formula	C7H4F4O
Molecular Weight	180.10 g/mol
Synonyms	1-Fluoro-4-(trifluoromethoxy)benzene; p-(Trifluoromethoxy)fluorobenzene; 4-Fluorophenyl trifluoromethyl ether; α,α,α-Trifluoro-p-fluoroanisole; 4-Fluoro-α,α,α-trifluoroanisole; F-TFMB; 352-67-0; Benzene, 1-fluoro-4-(trifluoromethoxy)-
EINECS	206-525-8

Quality Control

Our 4-(Trifluoromethoxy)Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.35 - 1.45 g/mL
Refractive Index (n20D)	1.390 - 1.410

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.