Description

Ethyl 3,3,3-trifluoropropionate is a versatile fluorinated ester building block of significant importance in advanced organic synthesis. Its value lies in the introduction of the trifluoromethyl group, a key motif for modulating the physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials industries seeking to develop novel compounds with enhanced metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of trifluoromethyl-substituted active pharmaceutical ingredients (APIs) and bioactive molecules.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where the CF₃ group improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display and lighting technologies.
• Polymer & Coatings Modifier: Incorporated to create specialty polymers with unique surface properties, chemical resistance, and durability.
• Organic Synthesis Reagent: Employed in various reactions, including Reformatsky-type reactions and nucleophilic substitutions, to introduce the -CH₂CF₃ moiety.
• Fluorinated Surfactant Precursor: Used in the development of high-performance surfactants and surface-active agents.

Basic Information

Product Name	Ethyl 3,3,3-Trifluoropropionate
CAS No.	352-23-8
Molecular Formula	C₅H₇F₃O₂
Molecular Weight	156.10 g/mol
Synonyms	3,3,3-Trifluoropropionic Acid Ethyl Ester; Ethyl 3,3,3-Trifluoropropanoate; Trifluoropropionic Acid Ethyl Ester; 3,3,3-Trifluoroethyl Propionate; Ethyl β,β,β-Trifluoropropionate; NSC 9235; EINECS 206-525-0; 352-23-8
EINECS	206-525-0

Quality Control

Our Ethyl 3,3,3-trifluoropropionate is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-25°C. The container should be kept tightly sealed in a dry environment to minimize moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.335 - 1.345
Density (20°C)	1.20 - 1.25 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.