Description

n-(2,2,2-Trifluoroethyl)Aniline is a specialized aromatic amine derivative featuring a trifluoroethyl substituent, offering unique reactivity and physicochemical properties. This compound serves as a critical fluorinated building block in advanced organic synthesis, enabling the introduction of fluorine atoms to enhance molecular stability, lipophilicity, and biological activity. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and pesticides where the trifluoroethyl group improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display and lighting technologies.
• Polymer Modification: Incorporated as a functional monomer to impart special properties like chemical resistance and low surface energy to polymers.
• Dye & Pigment Industry: Serves as an intermediate for synthesizing specialized fluorinated colorants.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) to create complex aniline derivatives.

Basic Information

Product Name	n-(2,2,2-Trifluoroethyl)Aniline
CAS No.	351-61-1
Molecular Formula	C8H8F3N
Molecular Weight	175.15 g/mol
Synonyms	N-(2,2,2-Trifluoroethyl)aniline; 2,2,2-Trifluoro-N-phenylethanamine; N-Phenyl-2,2,2-trifluoroethylamine; α,α,α-Trifluoro-N-ethylaniline; 1-(Trifluoroethyl)aminobenzene; Aniline, N-(2,2,2-trifluoroethyl)-; N-(Trifluoroethyl)aniline; 351-61-1
EINECS	206-517-5

Quality Control

Our n-(2,2,2-Trifluoroethyl)Aniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR), to ensure high purity and consistency. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (20°C)	~1.25 g/cm³
Refractive Index (n20D)	~1.47

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.