Description

m-(Trifluoromethyl)Phenylacetic Acid is a versatile fluorinated aromatic building block essential for advanced organic synthesis. Its core value lies in the trifluoromethyl group, which imparts unique electronic and lipophilic properties to target molecules, enhancing their metabolic stability and bioavailability. This high-purity intermediate is critically needed by pharmaceutical, agrochemical, and material science R&D teams for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for non-steroidal anti-inflammatory drugs (NSAIDs) and other bioactive molecules where the trifluoromethyl group modulates potency and ADME properties.
• Agrochemical Synthesis: Building block for advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom's ability to improve pesticidal activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Used in the synthesis of fluorinated aromatic cores for electronic display and lighting applications, where it influences charge transport and emission characteristics.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Serves as a versatile starting material or coupling partner in cross-coupling reactions, esterifications, and amide bond formations for complex molecule assembly.
• Chemical Research & Development: Fundamental reagent in academic and industrial labs for exploring new fluorination chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	m-(Trifluoromethyl)Phenylacetic Acid
CAS No.	351-35-9
Molecular Formula	C9H7F3O2
Molecular Weight	204.15 g/mol
Synonyms	3-(Trifluoromethyl)phenylacetic Acid; α-(3-Trifluoromethylphenyl)acetic Acid; m-Trifluoromethylphenylacetic Acid; 3-(Trifluoromethyl)benzeneacetic Acid; (3-Trifluoromethylphenyl)ethanoic Acid; 2-[3-(Trifluoromethyl)phenyl]acetic Acid; MTPAA; 351-35-9
EINECS	206-517-5

Quality Control

Our m-(Trifluoromethyl)Phenylacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.