Description

p-Toluidine Trifluoroacetamide is a specialized trifluoroacetylated aniline derivative, serving as a high-value synthetic intermediate in advanced organic synthesis. Its core value lies in providing a protected amine group and introducing the trifluoromethyl moiety, which is critical for modulating the physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the metabolic stability and lipophilicity conferred by the trifluoromethyl group.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoroacetamide group acts as a versatile synthetic handle.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced organic materials with tailored properties.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for catalysis and molecular recognition studies.
• Fluorine Chemistry: A valuable reagent for introducing fluorine atoms into complex organic frameworks in medicinal and materials chemistry.
• Chemical Research & Development: Used as a standard or intermediate in method development and scale-up processes for fine chemical production.

Basic Information

Product Name	p-Toluidine Trifluoroacetamide
CAS No.	350-96-9
Molecular Formula	C9H8F3NO
Molecular Weight	203.16 g/mol
Synonyms	N-(4-Methylphenyl)-2,2,2-trifluoroacetamide; 4-Methyl-N-(trifluoroacetyl)aniline; p-Tolyltrifluoroacetamide; 2,2,2-Trifluoro-N-(p-tolyl)acetamide; 4-Methylphenyltrifluoroacetamide; N-(p-Tolyl)trifluoroacetamide; Trifluoroacetic acid p-toluidide; 4-Methylaniline trifluoroacetamide
EINECS	Contact for details

Quality Control

Our p-Toluidine Trifluoroacetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.