Description

3-Phenyl-1,1,1-Trifluoropropan-2-One is a versatile fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethyl group adjacent to the carbonyl, making it a key precursor for pharmaceuticals and agrochemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl groups to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF3 group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of novel fluorinated polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology Probes: Useful for creating tagged molecules and probes for studying biological mechanisms and drug discovery.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Phenyl-1,1,1-Trifluoropropan-2-One
CAS No.	350-92-5
Molecular Formula	C9H7F3O
Molecular Weight	188.15 g/mol
Synonyms	1,1,1-Trifluoro-3-phenylpropan-2-one; 3-Phenyl-1,1,1-trifluoroacetone; 2-Propanone, 1,1,1-trifluoro-3-phenyl-; Benzyl trifluoromethyl ketone; α-(Trifluoroacetyl)toluene; ω,ω,ω-Trifluoroacetophenone; Phenyl trifluoromethyl ketone (related); TFAP
EINECS	206-500-2

Quality Control

Our production of 3-Phenyl-1,1,1-Trifluoropropan-2-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We operate under a quality system designed to meet the demands of cGMP and ISO standards for fine chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.