Description

n-Trifluoroacetyl-L-Phenylalanine is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound serves as a critical chiral building block and protecting group intermediate, enabling the precise construction of complex peptide and pharmaceutical molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and process development.

Application

• Peptide Synthesis Intermediate: A key protected amino acid derivative for solid-phase and solution-phase peptide synthesis, particularly for introducing the phenylalanine residue.
• Pharmaceutical Building Block: Used in the research and development of novel active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation Reagent: Facilitates the site-specific modification of proteins, antibodies, and other biomolecules for therapeutic and diagnostic applications.
• Chiral Auxiliary/Resolving Agent: Employed in asymmetric synthesis and for the resolution of racemic mixtures due to its stable chiral center.
• Protecting Group Chemistry: The trifluoroacetyl (TFA) group provides a base-labile protecting strategy for amine functionalities in multi-step syntheses.
• Chemical Biology Research: A valuable tool compound for studying enzyme mechanisms, metabolic pathways, and protein-protein interactions.

Basic Information

Product Name	n-Trifluoroacetyl-L-Phenylalanine
CAS No.	350-09-4
Molecular Formula	C11H10F3NO3
Molecular Weight	261.20 g/mol
Synonyms	N-(Trifluoroacetyl)-L-phenylalanine; L-Phenylalanine, N-(trifluoroacetyl)-; N-TFA-L-Phenylalanine; (S)-2-(Trifluoroacetamido)-3-phenylpropanoic acid; TFA-Phe-OH; Trifluoroacetylphenylalanine; 2-[(Trifluoroacetyl)amino]-3-phenylpropanoic acid; N-α-Trifluoroacetyl-L-phenylalanine
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetyl-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for research and synthesis. A Certificate of Analysis (COA) detailing purity, specific rotation, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Specific Rotation	-20° to -25° (c=1 in methanol)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.