Description

3,5-Bis(Trifluoromethyl)Anisole is a high-value fluorinated aromatic building block characterized by its electron-deficient aromatic ring and trifluoromethyl substituents. This compound is essential for introducing lipophilicity and metabolic stability into target molecules, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and electronic materials to modify dielectric properties and chemical resistance.
• Chemical Research & Development: A versatile building block for exploring novel reaction pathways and creating compound libraries for high-throughput screening.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Anisole
CAS No.	349-60-0
Molecular Formula	C9H5F6O
Molecular Weight	244.13 g/mol
Synonyms	1-Methoxy-3,5-bis(trifluoromethyl)benzene; 3,5-Bis(trifluoromethyl)phenyl methyl ether; Anisole, 3,5-bis(trifluoromethyl)-; Benzene, 1-methoxy-3,5-bis(trifluoromethyl)-; 3,5-Di(trifluoromethyl)anisole; Methyl 3,5-bis(trifluoromethyl)phenyl ether
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Anisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles for pharmaceutical-grade material, ensuring traceability and reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.