Description

Ethyl 2-Fluoropropionate is a versatile fluorinated ester building block of significant interest in advanced organic synthesis. Its value lies in the strategic introduction of a fluorine atom, which can dramatically alter the physicochemical and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced metabolic stability, bioavailability, or lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated active pharmaceutical ingredients (APIs), including potential protease inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, pesticides, and fungicides where fluorine substitution is critical for activity.
• Advanced Material Precursor: Serves as a monomer or modifying agent in the synthesis of specialty polymers and liquid crystals with tailored properties.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and coupling reactions to introduce the 2-fluoropropionate moiety into complex molecular architectures.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial R&D exploring new fluorination methodologies and structure-activity relationships (SAR).
• Flavor & Fragrance Intermediate: Potential use in the synthesis of novel fluorinated aroma chemicals, subject to regulatory approval and safety assessment.

Basic Information

Product Name	Ethyl 2-Fluoropropionate
CAS No.	349-43-9
Molecular Formula	C5H9FO2
Molecular Weight	120.12 g/mol
Synonyms	2-Fluoropropionic Acid Ethyl Ester; Ethyl α-Fluoropropionate; Ethyl 2-Fluoropropanoate; Propanoic acid, 2-fluoro-, ethyl ester; NSC 406906; Ethyl 2-fluoropropionate; α-Fluoropropionic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Fluoropropionate is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for manufacturing controls where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from strong bases and heat sources. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (20°C)	~1.05 g/cm³
Refractive Index (n20D)	~1.380

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.