Description

Tfa-L-Val-Oh CAS NO 349-00-8 is a high-purity, protected amino acid derivative, specifically N-Trifluoroacetyl-L-valine. This compound serves as a critical chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, ensuring stereochemical integrity and process efficiency. It is essential for research and production in the pharmaceutical, biotechnology, and fine chemical sectors, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-based drugs and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected valine residue to prevent racemization and control coupling reactions.
• Bioconjugation & Labeling: Facilitates the site-specific modification of peptides and proteins for diagnostic and therapeutic applications.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in the preparation of enantiomerically pure compounds for agrochemicals and specialty chemicals.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and bioactive compounds.
• Custom Synthesis: Serves as a foundational component for contract research and manufacturing organizations (CROs/CMOs) producing bespoke molecules.

Basic Information

Product Name	Tfa-L-Val-Oh
CAS No.	349-00-8
Molecular Formula	C7H10F3NO3
Molecular Weight	213.16 g/mol
Synonyms	N-Trifluoroacetyl-L-valine; (S)-2-(Trifluoroacetamido)-3-methylbutanoic acid; L-Valine, N-(trifluoroacetyl)-; TFA-L-Valine; Trifluoroacetyl-L-valine; N-TFA-L-valine; 2-[(Trifluoroacetyl)amino]-3-methylbutanoic acid; NSC 3349
EINECS	Contact for details

Quality Control

Our Tfa-L-Val-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical development and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.