Description

3-Trifluoromethylbutyric Acid is a versatile fluorinated carboxylic acid building block of significant importance in advanced organic synthesis. Its unique structure, featuring a trifluoromethyl group, imparts valuable properties such as enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with improved performance profiles.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated motifs to modulate bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes due to its influence on electronic properties.
• Polymer & Resin Modification: Incorporated to create specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Employed in various name reactions (e.g., esterifications, amide couplings) to introduce the trifluoromethylbutyryl moiety into complex molecules.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing novel fluorinated aroma chemicals, though specific applications require regulatory evaluation.

Basic Information

Product Name	3-Trifluoromethylbutyric Acid
CAS No.	348-75-4
Molecular Formula	C5H7F3O2
Molecular Weight	156.10 g/mol
Synonyms	3-(Trifluoromethyl)butanoic Acid; 4,4,4-Trifluoro-3-methylbutyric Acid; β-Methyl-4,4,4-trifluorobutyric Acid; 3-Trifluoromethylbutanoic Acid; 3-Methyl-4,4,4-trifluorobutyric Acid; Butanoic acid, 3-(trifluoromethyl)-; NSC 163045
EINECS	206-493-7

Quality Control

Our 3-Trifluoromethylbutyric Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Containers should be kept tightly sealed when not in use to minimize moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.365 - 1.375
Density (20°C)	1.28 - 1.32 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.