Description

1-Bromo-3,4-difluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to introduce difluorophenyl motifs into target structures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs containing difluorobenzene cores.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated compounds for electronic displays and organic light-emitting diodes (OLEDs).
• Polymer & Specialty Chemicals: Employed in the synthesis of specialty monomers and polymers, including high-performance resins and coatings.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	1-Bromo-3,4-difluorobenzene
CAS No.	348-61-8
Molecular Formula	C6H3BrF2
Molecular Weight	192.99 g/mol
Synonyms	3,4-Difluorobromobenzene; 3,4-Difluorophenyl Bromide; 1-Bromo-3,4-difluorobenzol; Benzene, 1-bromo-3,4-difluoro-; 348-61-8; NSC 88253; 3,4-Difluoro-1-bromobenzene; 3,4-Difluorobenzenebromide
EINECS	206-479-6

Quality Control

Our 1-Bromo-3,4-difluorobenzene is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring reliable and traceable raw materials for GMP and research purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.7 g/mL
Boiling Point	~165-167 °C
Refractive Index (n20D)	~1.51

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.