Description

1-Bromo-2,4-Difluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of bromine and fluorine atoms on the benzene ring, enabling selective functionalization and serving as a key precursor for complex molecules. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials sectors who require high-purity intermediates for coupling reactions and the development of active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing difluorophenyl or aryl bromide motifs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science: Serves as a monomer or precursor in the development of liquid crystals, organic semiconductors, and specialty polymers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Research & Development: Employed in academic and industrial labs for method development and exploring new synthetic pathways in organofluorine chemistry.
• Ligand and Catalyst Preparation: Used to synthesize sophisticated phosphine or nitrogen-based ligands for catalytic systems.

Basic Information

Item	Detail
Product Name	1-Bromo-2,4-Difluorobenzene
CAS No.	348-57-2
Molecular Formula	C6H3BrF2
Molecular Weight	192.99 g/mol
Synonyms	2,4-Difluorobromobenzene; 2,4-Difluoro-1-bromobenzene; 1-Bromo-2,4-difluorobenzene; 2,4-Difluorophenyl bromide; Bromo-2,4-difluorobenzene; o,p-Difluorobromobenzene; Benzene, 1-bromo-2,4-difluoro-; (2,4-Difluorophenyl)bromide
EINECS	206-487-5

Quality Control

Our 1-Bromo-2,4-Difluorobenzene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide full traceability and a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring stringent material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place away from incompatible materials such as strong bases and metals. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.7 g/cm³
Boiling Point	~165-167 °C
Refractive Index (n20D)	~1.51

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.