Description

1-Ethoxy-2,4-Difluorobenzene is a versatile fluorinated aromatic ether building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine and ethoxy substituents, which allows for precise tuning of electronic properties and reactivity in target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluorobenzene moiety contributes to efficacy and environmental profile.
• Liquid Crystal & Electronic Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic electronic materials due to its ability to modify dielectric constant and molecular alignment.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the 2,4-difluoro-1-ethoxybenzene fragment into more complex structures.
• Chemical Research & Development: Essential for method development and exploring new reaction pathways in academic and industrial R&D settings focused on fluorochemistry.

Basic Information

Product Name	1-Ethoxy-2,4-Difluorobenzene
CAS No.	348-20-9
Molecular Formula	C8H8F2O
Molecular Weight	158.15 g/mol
Synonyms	2,4-Difluoro-1-ethoxybenzene; 2,4-Difluorophenyl ethyl ether; Ethyl 2,4-difluorophenyl ether; 1-Ethoxy-2,4-difluorobenzene; 2,4-Difluoroanisole (common misnomer, correctly anisole is methoxy); Benzene, 1-ethoxy-2,4-difluoro-; p-Ethoxy-o,o'-difluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Ethoxy-2,4-Difluorobenzene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality systems are designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.15 g/cm³
Refractive Index (n20D)	~1.46

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.