Description

(1S,2S)-(+)-Pseudoephedrine Hydrochloride is a high-purity, single-enantiomer pharmaceutical active ingredient. This compound is valued for its potent and selective adrenergic agonist activity, making it a critical intermediate in the synthesis of advanced decongestant medications. It is primarily required by pharmaceutical manufacturers and advanced research institutions for the development and production of controlled, effective cold and allergy remedies.

Application

• Pharmaceutical Synthesis: Primary active pharmaceutical ingredient (API) in prescription and over-the-counter oral decongestants.
• Chiral Intermediate: Key building block in the asymmetric synthesis of more complex adrenergic agents and related therapeutic molecules.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of drug products.
• Clinical Research: Employed in pharmacological studies to investigate nasal decongestion and bronchodilation mechanisms.
• Formulation Development: Utilized in R&D for developing sustained-release tablets, capsules, and liquid formulations.

Basic Information

Product Name	(1S,2S)-(+)-Pseudoephedrine Hydrochloride
CAS No.	345-78-8
Molecular Formula	C10H15NO•HCl
Molecular Weight	201.69 g/mol
Synonyms	(+)-Pseudoephedrine HCl; d-Pseudoephedrine Hydrochloride; (1S,2S)-2-Methylamino-1-phenylpropan-1-ol Hydrochloride; Pseudoephedrine Hydrochloride USP; Sudafed (active ingredient); Isoephedrine Hydrochloride; d-Isoephedrine Hydrochloride
EINECS	206-465-9

Quality Control

Our (1S,2S)-(+)-Pseudoephedrine Hydrochloride is manufactured under strict quality management systems. Each batch is tested to meet stringent specifications, including identity, purity, and impurity profiles, aligning with major pharmacopoeial standards such as USP. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and regulatory compliance for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in its original packaging until use to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Specific Rotation	+61.0° to +62.5° (c=5 in water)
Water Content (KF)	NMT 0.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities NMT 1.0% Any individual impurity NMT 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.