Description

1-Trifluoroacetyl Piperidine is a high-value fluorinated building block and key intermediate in advanced organic synthesis. This compound matters for its ability to introduce the metabolically stable and electron-withdrawing trifluoroacetyl group into complex molecular architectures. It is primarily needed by pharmaceutical, agrochemical, and specialty chemical R&D teams for applications in medicinal chemistry, process development, and the creation of novel materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and metabolic disorder drugs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine moiety enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced organic materials with unique surface properties and chemical resistance.
• Chemical Biology Probes: Utilized to develop fluorinated probes and tags for studying enzyme mechanisms and protein interactions.
• Custom Synthesis and Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	1-Trifluoroacetyl Piperidine
CAS No.	340-07-8
Molecular Formula	C7H10F3NO
Molecular Weight	181.16 g/mol
Synonyms	N-(Trifluoroacetyl)piperidine; Piperidine, 1-(trifluoroacetyl)-; 1-Piperidinyl trifluoromethyl ketone; Trifluoroacetic acid piperidide; α,α,α-Trifluoro-N-piperidylacetamide; TFAP
EINECS	206-421-4

Quality Control

Our 1-Trifluoroacetyl Piperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.25 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.