Description

3-Hydroxy-3-Methyl-4,4,4-Trifluorobutyric Acid is a versatile fluorinated organic acid building block. Its unique structure, featuring both a hydroxyl group and a trifluoromethyl moiety, makes it a critical intermediate for synthesizing advanced molecules with enhanced properties. This compound is essential for R&D and production in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is a key strategy for modulating bioactivity and stability. Its reactivity profile allows for selective functionalization, enabling the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal displays (LCDs), contributing to improved dielectric anisotropy and thermal stability.
• Advanced Polymer Modifiers: Incorporated as a monomer or chain modifier to introduce fluorine into polymers, enhancing chemical resistance, surface properties, and weatherability.
• Organic Synthesis Building Block: Employed in medicinal and combinatorial chemistry for the construction of complex, fluorinated molecular scaffolds.
• Fluorinated Surfactant Precursor: Acts as a starting material for synthesizing specialty surfactants with superior wetting and leveling properties.

Basic Information

Product Name	3-Hydroxy-3-Methyl-4,4,4-Trifluorobutyric Acid
CAS No.	338-03-4
Molecular Formula	C5H7F3O3
Molecular Weight	172.10 g/mol
Synonyms	3-Hydroxy-3-methyl-4,4,4-trifluorobutanoic Acid; 4,4,4-Trifluoro-3-hydroxy-3-methylbutyric Acid; 3-Methyl-3-hydroxy-4,4,4-trifluorobutyric Acid; HMTA; 3-Hydroxy-3-methyl-4,4,4-trifluorobutanoate; 3-Hydroxy-3-methyl-4,4,4-trifluorobutyrate; 338-03-4; NSC 163044
EINECS	206-403-6

Quality Control

Our 3-Hydroxy-3-Methyl-4,4,4-Trifluorobutyric Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality commitment supports applications requiring high-purity intermediates, including cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.