Description

3-Fluorophenylacetic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the phenylacetic acid scaffold bearing a fluorine substituent, which is crucial for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs), fluorinated analogs of existing APIs, and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances efficacy and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for fluorinated liquid crystals and organic light-emitting diode (OLED) components, improving electronic properties and stability.
• Peptide Mimetics & Protease Inhibitors: Incorporated into peptide backbones to create fluorinated analogs that resist enzymatic degradation for drug discovery.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of PET (Positron Emission Tomography) imaging agents, though typically requiring specialized handling.
• General Organic Synthesis: Employed in various name reactions, such as Friedel-Crafts alkylations and coupling reactions, to introduce the fluorophenylacetic moiety.

Basic Information

Product Name	3-Fluorophenylacetic Acid
CAS No.	331-25-9
Molecular Formula	C8H7FO2
Molecular Weight	154.14 g/mol
Synonyms	(3-Fluorophenyl)acetic Acid; 3-Fluorobenzeneacetic Acid; m-Fluorophenylacetic Acid; 2-(3-Fluorophenyl)acetic Acid; 3-Fluoro-α-toluic Acid; 3-Fluorobenzylcarboxylic Acid; NSC 404087; FPA
EINECS	206-357-9

Quality Control

Our 3-Fluorophenylacetic Acid is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research-grade chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	85 - 89 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.