Description

3,5-Bis(Trifluoromethyl)Iodobenzene is a high-value, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring iodine and two trifluoromethyl groups, makes it a critical intermediate for introducing fluorine atoms and enabling cross-coupling reactions. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and materials science industries for developing novel active ingredients and specialty polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases where the trifluoromethyl group enhances bioavailability and metabolic stability.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved lipophilicity, membrane penetration, and environmental persistence of the final product.
• Ligand & Catalyst Development: Serves as a starting material for creating sophisticated ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Materials Science Research: Employed in the development of organic electronic materials, liquid crystals, and specialty polymers, where the fluorinated aromatic core modifies electronic properties and thermal stability.
• Cross-Coupling Reactions: The iodine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Heck couplings, enabling rapid diversification of molecular scaffolds.
• Fluorine Chemistry Library Building: A fundamental reagent for constructing diverse compound libraries in medicinal chemistry for high-throughput screening and structure-activity relationship (SAR) studies.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Iodobenzene
CAS No.	328-73-4
Molecular Formula	C8H3F6I
Molecular Weight	339.99 g/mol
Synonyms	1-Iodo-3,5-bis(trifluoromethyl)benzene; 3,5-Di(trifluoromethyl)iodobenzene; 3,5-Bis(trifluoromethyl)phenyl iodide; α,α,α,α',α',α'-Hexafluoro-3,5-diiodotoluene (related); 3,5-Bis(trifluoromethyl)benzen iodide; 328-73-4 (CAS Registry Number); Iodobenzene, 3,5-bis(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 3,5-Bis(Trifluoromethyl)Iodobenzene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality protocols are designed to support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.