Description

3,5-Bis(Trifluoromethyl)Chlorobenzene is a high-value, multi-functional fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring two strong electron-withdrawing trifluoromethyl groups and a reactive chlorine substituent, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials sectors for developing new active ingredients and high-performance polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology, where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where its fluorinated aromatic core contributes to improved efficacy and environmental persistence.
• Ligand and Catalyst Development: Serves as a backbone for synthesizing sophisticated ligands used in transition metal catalysis, enabling more efficient and selective chemical transformations.
• Material Science: Employed in the production of specialty polymers, liquid crystals, and electronic materials, where the introduction of fluorine atoms modifies thermal stability, solubility, and dielectric properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce the valuable 3,5-bis(trifluoromethyl)phenyl moiety into complex molecular architectures.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Chlorobenzene
CAS No.	328-72-3
Molecular Formula	C8H3ClF6
Molecular Weight	248.55 g/mol
Synonyms	1-Chloro-3,5-bis(trifluoromethyl)benzene; 3,5-Bis(trifluoromethyl)phenyl chloride; α,α,α,α',α',α'-Hexafluoro-3,5-xylyl chloride; 3,5-Di(trifluoromethyl)chlorobenzene; 3,5-Bis(trifluoromethyl)-1-chlorobenzene; 3,5-(CF3)2C6H3Cl
EINECS	206-333-8

Quality Control

Every batch of 3,5-Bis(Trifluoromethyl)Chlorobenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from GC, HPLC, and NMR analyses, is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 2°C and 25°C. The container should be kept tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.