Description

4-Chloro-3-(Trifluoromethyl)Phenyl Isocyanate is a versatile and highly reactive aromatic isocyanate building block. Its value lies in its ability to introduce both a chloro and a trifluoromethyl substituent pattern into advanced chemical structures, imparting unique physicochemical properties. This compound is essential for researchers and manufacturers in the agrochemical and pharmaceutical industries, where it serves as a key intermediate in the synthesis of active ingredients and functional materials.

Application

• Agrochemical Intermediate: A critical precursor for synthesizing novel herbicides, fungicides, and insecticides, where the chloro and trifluoromethyl groups enhance biological activity and environmental stability.
• Pharmaceutical Synthesis: Used in the development of active pharmaceutical ingredients (APIs), particularly in creating urea and carbamate derivatives with targeted therapeutic effects.
• Polymer & Material Science: Serves as a monomer or cross-linking agent in the production of specialized polyurethanes, coatings, and adhesives with enhanced chemical resistance.
• Chemical Research & Development: Employed as a versatile reagent for introducing the phenyl isocyanate moiety into complex molecules for structure-activity relationship (SAR) studies.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of advanced colorants and functional dyes.

Basic Information

Product Name	4-Chloro-3-(Trifluoromethyl)Phenyl Isocyanate
CAS No.	327-78-6
Molecular Formula	C8H3ClF3NO
Molecular Weight	221.56 g/mol
Synonyms	1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene; 3-Trifluoromethyl-4-chlorophenyl isocyanate; 4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate; 4-Chloro-3-trifluoromethylphenyl isocyanate; Isocyanic acid, 4-chloro-3-(trifluoromethyl)phenyl ester; 2-(Trifluoromethyl)-4-chlorophenyl isocyanate; m-Chloro-α,α,α-trifluoro-p-tolyl isocyanate
EINECS	206-333-3

Quality Control

Our production of 4-Chloro-3-(Trifluoromethyl)Phenyl Isocyanate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We are committed to meeting the rigorous standards required for pharmaceutical and agrochemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maximize stability. This product is hygroscopic (moisture-sensitive) and must be kept under a dry inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, open flames, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.5 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.