Description

4-Bromo-1,3-Bis(trifluoromethyl)benzene is a high-value, multi-functional aromatic building block distinguished by its bromine and trifluoromethyl substituents. This compound is critical for introducing both halogen and fluorinated motifs into advanced molecular architectures, enabling precise tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and materials science sectors for synthesizing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology, where the trifluoromethyl group enhances bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where its structure contributes to improved pest selectivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a core building block in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, where it helps optimize charge transport and emission properties.
• Polymer & Specialty Chemicals: Employed to create monomers and additives for high-performance polymers, coatings, and surfactants that require enhanced chemical resistance and thermal stability.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira), facilitating rapid diversification in medicinal chemistry libraries.
• Fluorine Chemistry Research: An essential reagent in academic and industrial laboratories studying the effects of fluorination on molecular properties and reaction pathways.

Basic Information

Product Name	4-Bromo-1,3-Bis(trifluoromethyl)benzene
CAS No.	327-75-3
Molecular Formula	C8H3BrF6
Molecular Weight	292.99 g/mol
Synonyms	1-Bromo-2,4-Bis(trifluoromethyl)benzene; 2,4-Bis(trifluoromethyl)bromobenzene; 4-Bromo-α,α,α,α',α',α'-Hexafluoro-m-xylene; 4-Bromo-1,3-Bis(trifluoromethyl)benzol; 4-Bromo-1,3-di(trifluoromethyl)benzene; 4-Bromo-m-bis(trifluoromethyl)benzene; 4-Bromo-m-xylene hexafluoride
EINECS	206-322-6

Quality Control

Every batch of 4-Bromo-1,3-Bis(trifluoromethyl)benzene is manufactured and tested under a strict quality management system. We guarantee high purity and batch-to-batch consistency through rigorous analytical protocols including GC, HPLC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure it meets your precise research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent and high volatility, keep away from heat, sparks, and open flames. Ensure containers are kept upright and securely sealed to prevent evaporation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.8 g/mL
Refractive Index (n20D)	~1.42

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.