Description

1-Bromo-2,4,5-trifluorobenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of bromine and fluorine atoms, which enables selective functionalization and introduces desirable physicochemical properties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require high-purity intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a fluorinated benzene core for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atoms improve lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations for carbon-carbon and carbon-heteroatom bond formation.
• Fluorine Chemistry Research: A valuable reagent for studying nucleophilic aromatic substitution and other reactions specific to polyfluorinated arenes.
• Polymer Modification: Incorporated as a monomer or modifier to impart specific properties like chemical resistance or altered refractive index into specialty polymers.

Basic Information

Product Name	1-Bromo-2,4,5-trifluorobenzene
CAS No.	327-52-6
Molecular Formula	C6H2BrF3
Molecular Weight	210.98 g/mol
Synonyms	2,4,5-Trifluorobromobenzene; 2-Bromo-1,4,5-trifluorobenzene; Benzene, 1-bromo-2,4,5-trifluoro-; 3-Bromo-1,2,4-trifluorobenzene (isomer); NSC 88262; BTFB
EINECS	206-322-5

Quality Control

Our 1-Bromo-2,4,5-trifluorobenzene is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for our customers' quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to prevent moisture ingress and minimize evaporation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.