Description

1,4-Dibromo-2,5-difluorobenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its precise molecular architecture, featuring bromine and fluorine substituents in specific positions, makes it a critical intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require reliable, high-quality raw materials for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a difluorobenzene core with sites for further functionalization.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the halogenated benzene ring contributes to biological activity and stability.
• Liquid Crystal & OLED Materials: Serves as a building block for creating fluorinated aromatic components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to introduce fluorine and bromine functional groups into polymer backbones, enhancing properties like chemical resistance and thermal stability.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions such as Suzuki, Stille, and Buchwald-Hartwig couplings, enabling the formation of complex biaryl structures.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in exploring new synthetic methodologies and creating novel fluorinated compounds.

Basic Information

Item	Details
Product Name	1,4-Dibromo-2,5-Difluorobenzene
CAS No.	327-51-5
Molecular Formula	C6H2Br2F2
Molecular Weight	271.89 g/mol
Synonyms	2,5-Difluoro-1,4-dibromobenzene; Benzene, 1,4-dibromo-2,5-difluoro-; 1,4-Dibromo-2,5-difluorobenzol; p-Dibromo-o,p'-difluorobenzene
EINECS	Contact for details

Quality Control

Our 1,4-Dibromo-2,5-difluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment ensures the material meets the stringent requirements for use in GMP-compliant pharmaceutical and advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	72 - 76 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.