Description

5-Trifluoromethyl-1H-Benzimidazole is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in developing active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl group imparts desirable metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate new molecular entities.

Application

• Pharmaceutical Intermediate: A critical scaffold in the synthesis of novel drug candidates, particularly for antiviral, anticancer, and anti-inflammatory therapies.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, leveraging the bioactivity of the benzimidazole core.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design of enzyme inhibitors and molecular probes for biochemical research.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis services catering to specific client R&D projects.

Basic Information

Product Name	5-Trifluoromethyl-1H-Benzimidazole
CAS No.	326-55-6
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	5-(Trifluoromethyl)-1H-benzimidazole; 5-Trifluoromethylbenzimidazole; 1H-Benzimidazole, 5-(trifluoromethyl)-; 5-Trifluoromethyl-1H-benzo[d]imidazole; 326-55-6; 5-CF3-Benzimidazole; 5-Trifluoromethylbenzimidazole; Benzimidazole, 5-trifluoromethyl-
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-1H-Benzimidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.