Description

2-Fluoroanisole is a versatile fluorinated aromatic ether, serving as a critical building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the fluorine atom and methoxy group, enabling precise molecular modifications. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries seeking to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, including potential CNS-active compounds and kinase inhibitors.
• Agrochemical Synthesis: Used in creating novel herbicides, pesticides, and fungicides where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a starting material for fluorinated mesogens and electron-transport layers in display technologies.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce fluoromethoxy phenyl motifs.
• Dye & Pigment Industry: Intermediate for synthesizing specialized fluorinated dyes with altered spectral properties and improved fastness.
• Polymer Modification: Used to incorporate fluorinated aromatic units into polymer backbones, enhancing thermal stability and chemical resistance.

Basic Information

Product Name	2-Fluoroanisole
CAS No.	321-28-8
Molecular Formula	C7H7FO
Molecular Weight	126.13 g/mol
Synonyms	1-Fluoro-2-methoxybenzene; o-Fluoroanisole; 2-Methoxyfluorobenzene; Fluoromethoxybenzene; 2-Fluorophenyl methyl ether; ortho-Fluoroanisole; F-Anisole (o-); Benzene, 1-fluoro-2-methoxy-
EINECS	206-280-1

Quality Control

Our 2-Fluoroanisole is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing including GC, HPLC, and NMR to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, keep containers tightly sealed when not in use. Recommended storage temperature: 2°C to 25°C.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	1.10 - 1.15 g/mL
Refractive Index (n20D)	1.480 - 1.490

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.