Description

4-(Trifluoromethylsulfonyl)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring a potent electron-withdrawing trifluoromethanesulfonyl (triflyl) group. This compound matters for its unique ability to impart exceptional chemical stability, lipophilicity, and metabolic resistance in advanced molecular frameworks, making it a critical building block for performance-driven applications. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty materials industries seeking to enhance the properties of their target molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics where the triflyl group modulates bioavailability and target binding.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where its structural motif contributes to weatherfastness and pest resistance.
• Ligand & Catalyst Precursor: Serves as a precursor for sophisticated ligands in transition metal catalysis, enabling challenging cross-coupling and functionalization reactions.
• Functional Material Development: Incorporated into organic electronic materials, such as electron-transport layers (ETLs) in OLEDs or as a building block for high-performance polymers.
• Fluorinated Liquid Crystal Synthesis: A valuable intermediate for creating fluorinated mesogens used in display technologies.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new reaction methodologies and constructing complex, fluorinated molecular architectures.

Basic Information

Product Name	4-(Trifluoromethylsulfonyl)Benzonitrile
CAS No.	312-21-0
Molecular Formula	C8H4F3NO2S
Molecular Weight	235.18 g/mol
Synonyms	4-(Trifluoromethanesulfonyl)benzonitrile; p-(Trifluoromethylsulfonyl)benzonitrile; α,α,α-Trifluoro-p-cyanobenzenesulfonamide; 4-Cyanophenyl trifluoromethyl sulfone; Benzonitrile, 4-[(trifluoromethyl)sulfonyl]-; 4-Triflylbenzonitrile; p-Triflylbenzonitrile; 4-(Trifluoromethanesulfonyl)phenyl cyanide
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethylsulfonyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.