Description

Allotetrahydrocortisol CAS NO 302-91-0 is a significant metabolite of cortisol, belonging to the class of corticosteroids. This compound serves as a crucial reference standard and intermediate in pharmaceutical research and development, particularly in the study of steroid metabolism and endocrine function. It is primarily utilized by research institutions, pharmaceutical manufacturers, and analytical laboratories involved in hormone analysis, method validation, and the synthesis of more complex steroid derivatives.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of steroid metabolites in research and quality control laboratories.
• Biochemical Research: Serves as a key intermediate or substrate in studies investigating cortisol metabolism, enzymatic pathways, and adrenal function.
• Diagnostic Agent Development: Employed in the development and calibration of diagnostic assays and kits for measuring steroid hormone levels.
• Organic Synthesis: Acts as a sophisticated building block for the chemical synthesis of novel steroid-based therapeutic agents or labeled compounds.
• Metabolite Identification: Essential for the identification and characterization of cortisol metabolites in clinical and preclinical studies.

Basic Information

Product Name	Allotetrahydrocortisol
CAS No.	302-91-0
Molecular Formula	C21H34O5
Molecular Weight	366.49 g/mol
Synonyms	3α,11β,17α,21-Tetrahydroxy-5β-pregnan-20-one; 5β-Allotetrahydrocortisol; 5β-Tetrahydrocortisol; (3α,5β,11β)-3,11,17,21-Tetrahydroxypregnan-20-one; ATHF; allo-Tetrahydrocortisol; 5β-Pregnan-3α,11β,17α,21-tetrol-20-one
EINECS	Contact for details

Quality Control

Our Allotetrahydrocortisol is produced and handled under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for reference standards, ensuring reliable performance in analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which could affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.