Description

1,3-Benzoxaphosphole, 2-[Bis(1,1-Dimethylethyl)Phosphino]-3-(1,1-Dimethylethyl)-2,3-Dihydro-4-Methoxy-, (2R,3S)- is a high-purity, chiral organophosphorus compound with a defined stereochemistry, serving as a sophisticated ligand or building block in advanced chemical synthesis. Its value lies in its ability to impart precise stereocontrol and reactivity in catalytic transformations, which is critical for developing novel materials and active pharmaceutical ingredients (APIs). This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for asymmetric synthesis and catalysis.

Application

• Asymmetric Catalysis: Employed as a chiral phosphine ligand in transition metal-catalyzed reactions such as hydrogenation, cross-coupling, and hydroformylation to produce enantiomerically enriched compounds.
• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex drug molecules, particularly for central nervous system (CNS) and antiviral agents.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides, where specific stereochemistry is crucial for biological activity.
• Material Science Research: Acts as a precursor or functional additive in the development of novel polymers and advanced materials with tailored properties.
• Academic & Industrial R&D: A valuable tool for methodology development in organic synthesis and catalysis within university laboratories and corporate research centers.
• Ligand Library Development: Incorporated into screening libraries for high-throughput discovery of new catalytic systems.

Basic Information

Product Name	1,3-Benzoxaphosphole, 2-[Bis(1,1-Dimethylethyl)Phosphino]-3-(1,1-Dimethylethyl)-2,3-Dihydro-4-Methoxy-, (2R,3S)-
CAS No.	2828431-92-9
Molecular Formula	C19H31O2P
Molecular Weight	322.42 g/mol
Synonyms	(2R,3S)-2-(Di-tert-butylphosphino)-3-tert-butyl-4-methoxy-2,3-dihydro-1,3-benzoxaphosphole; (2R,3S)-2-(Bis(tert-butyl)phosphino)-3-tert-butyl-4-methoxy-2,3-dihydrobenzo[d][1,3]oxaphosphole; Chiral Benzoxaphosphole Ligand; tBu-BOXAP Ligand; DTBP-BOXAP; (R,S)-tBu-BOXAP; Asymmetric Phosphine Ligand; P-Chiral Ligand
EINECS	Contact for details

Quality Control

Every batch of this chiral compound is produced and analyzed under strict quality control protocols to ensure identity, purity, and enantiomeric excess meet the high standards required for research and process chemistry. Our comprehensive analytical suite includes chiral HPLC, NMR (¹H, ¹³C, ³¹P), and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.