Description

Dbco-Peg5-Ch2Ch2Cooh CAS NO 2764923-65-9 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a carboxylic acid terminus for further conjugation. This compound is essential for creating stable, bioorthogonal linkages in complex biomolecular assemblies without the need for cytotoxic copper catalysts. It is primarily utilized by researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science for constructing antibody-drug conjugates (ADCs), PEGylated therapeutics, and diagnostic probes.

Application

• Bioconjugation and ADC Development: Enables site-specific, copper-free click chemistry conjugation of payloads (e.g., drugs, toxins, dyes) to antibodies, proteins, or peptides.
• PEGylation Reagent: Acts as a functionalized PEG spacer to improve the pharmacokinetic properties (solubility, stability, circulation half-life) of therapeutic biomolecules.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and microarray surfaces with carboxylic acid groups for subsequent immobilization of biomolecules.
• Polymer and Dendrimer Synthesis: Serves as a key building block for constructing complex, branched polymeric architectures with defined functionality.
• Diagnostic Probe Assembly: Facilitates the creation of fluorescent, radioactive, or magnetic imaging agents for in vitro and in vivo diagnostics.
• Hydrogel and Biomaterial Crosslinking: Employed in the development of tunable, biocompatible hydrogels for drug delivery and tissue engineering applications.

Basic Information

Item	Detail
Product Name	Dbco-Peg5-Ch2Ch2Cooh
CAS No.	2764923-65-9
Molecular Formula	C₃₃H₄₉NO₁₀
Molecular Weight	619.75 g/mol
Synonyms	DBCO-PEG5-COOH; DBCO-PEG5-Acid; Dibenzocyclooctyne-PEG5-propionic acid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2,5,8,11,14-pentaoxahexadecan-16-yl)carbamate; Azadibenzocyclooctyne-PEG5-COOH; ADIBO-PEG5-COOH; DBCO-PEG(2000)-Acid (related); DBCO-PEG5-Propionic Acid
EINECS	Contact for details

Quality Control

Our Dbco-Peg5-Ch2Ch2Cooh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for critical research and development applications. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, NMR, and MS analysis to verify identity, purity, and absence of critical impurities.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.