Description

(4S,4'S)-2,2'-(1,3-Bis(4-(Adamantan-1-Yl)Phenyl)Propane-2,2-Diyl)Bis(4-Benzyl-4,5-Dihydrooxazole) is a sophisticated chiral bis(oxazoline) ligand, a critical component in asymmetric catalysis. Its value lies in its unique structural framework, featuring adamantyl and benzyl groups, which provides exceptional steric and electronic tuning for high enantioselectivity in metal-catalyzed reactions. This compound is essential for R&D chemists and process engineers in the pharmaceutical and fine chemical industries developing novel active ingredients and chiral intermediates.

Application

• Asymmetric Catalysis: As a privileged chiral ligand for copper, palladium, and other transition metals in enantioselective C-H activation, cyclopropanation, and Diels-Alder reactions.
• Pharmaceutical Intermediate Synthesis: Enabling the production of single-enantiomer drug candidates with high optical purity for therapeutic applications.
• Agrochemical Development: Used in the synthesis of chiral active ingredients for herbicides and pesticides to enhance efficacy and reduce environmental impact.
• Material Science Research: Serving as a building block or catalyst for creating chiral polymers and advanced functional materials.
• Academic & Industrial R&D: A key reagent for methodological development in organic synthesis and process chemistry optimization.

Basic Information

Product Name	(4S,4'S)-2,2'-(1,3-Bis(4-(Adamantan-1-Yl)Phenyl)Propane-2,2-Diyl)Bis(4-Benzyl-4,5-Dihydrooxazole)
CAS No.	2757085-43-9
Molecular Formula	C61H66N2O2
Molecular Weight	859.19 g/mol
Synonyms	(4S,4'S)-Adamantyl-BOX Ligand; (S,S)-Ad-Box; (4S,4'S)-2,2'-[1,3-Bis(4-adamantylphenyl)propane-2,2-diyl]bis(4-benzyl-4,5-dihydrooxazole); Chiral Bis(oxazoline) Ligand with Adamantyl Groups; (S,S)-t-Bu-Adamantyl-BOX; Asymmetric Catalyst Ligand 2757085-43-9; BOX Ligand Derivative
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Every lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical identity, high purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light). For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.