Description

Oxazole, 2-[2-Chloro-6-(Diphenylphosphino)Phenyl]-4-(1,1-Dimethylethyl)-4,5-Dihydro-, (4R)- is a high-value, chiral organophosphorus ligand with a CAS number of 2757082-51-0. This compound is specifically engineered to act as a sophisticated catalyst or ligand in asymmetric synthesis, enabling the production of enantiomerically pure intermediates critical for advanced pharmaceuticals and fine chemicals. It is an essential tool for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to optimize stereoselective transformations.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metals (e.g., Rh, Pd, Ir) in enantioselective hydrogenation, cross-coupling, and C-H activation reactions.
• Pharmaceutical Intermediate Synthesis: Key component in the synthesis of chiral active pharmaceutical ingredients (APIs) requiring high enantiomeric excess (ee).
• Agrochemical Research: Used in the development of novel, stereospecific herbicides, fungicides, and insecticides.
• Material Science: Potential ligand for creating chiral metal-organic frameworks (MOFs) or polymers with specific optical properties.
• Academic & Industrial R&D: A valuable reagent for methodology development in organic and organometallic chemistry laboratories.
• Process Chemistry Optimization: Employed to improve the yield, selectivity, and sustainability of large-scale chemical manufacturing processes.

Basic Information

Product Name	Oxazole, 2-[2-Chloro-6-(Diphenylphosphino)Phenyl]-4-(1,1-Dimethylethyl)-4,5-Dihydro-, (4R)-
CAS No.	2757082-51-0
Molecular Formula	C31H29ClNOP
Molecular Weight	497.99 g/mol
Synonyms	(4R)-2-[2-Chloro-6-(diphenylphosphino)phenyl]-4-(tert-butyl)-4,5-dihydrooxazole; (R)-2-(2-Chloro-6-(diphenylphosphanyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole; (R)-t-Bu-PHOX; Chloro-(R)-t-Bu-PHOX; (R)-2-[2-Chloro-6-(diphenylphosphino)phenyl]-4-(1,1-dimethylethyl)-4,5-dihydrooxazole; PHOX Ligand derivative; Chiral Dihydrooxazole Phosphine Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management protocols to ensure consistency and performance in sensitive catalytic applications. Standard quality parameters include chiral purity (enantiomeric excess) verified by chiral HPLC, identity confirmation by 1H/31P NMR and IR spectroscopy, and chemical purity assessment. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.