Description

Dantrolene-D4 is a deuterated isotopologue of the muscle relaxant dantrolene, specifically designed for use as an internal standard in analytical chemistry. This high-purity reference material is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic, and clinical diagnostics sectors who require precise measurement of dantrolene levels.

Application

• Primary use as an internal standard for the quantification of dantrolene in biological matrices (plasma, serum, urine) via LC-MS/MS and GC-MS.
• Metabolic pathway elucidation and drug metabolism and pharmacokinetics (DMPK) studies in pharmaceutical R&D.
• Method development and validation for forensic toxicology analysis.
• Quality control and assurance in the manufacturing of dantrolene sodium API and finished pharmaceutical products.
• Use in clinical research to monitor patient drug levels and ensure therapeutic efficacy.
• Stability-indicating assay development to track degradation products.

Basic Information

Product Name	Dantrolene-D4
CAS No.	2749234-17-9
Molecular Formula	C14H6D4N4O5
Molecular Weight	302.27 g/mol (approx.)
Synonyms	Dantrolene-d4; 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione-d4; Dantrium-d4; Dantamacrin-d4; Ryanodex-d4 (deuterated analog); Deuterated Dantrolene; Dantrolene Internal Standard; Dantrolene Isotopologue
EINECS	Contact for details

Quality Control

Every batch of Dantrolene-D4 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support your regulatory submissions, including Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and identity confirmation via spectroscopic methods. Our products are suitable for use in GLP and GMP-regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 98.0% (chemical purity)
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.